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(cell and molecular biology)
A submicroscopic structural unit of protoplasm built up from polymeric molecules.
(physical chemistry)
A colloidal aggregate of a unique number (between 50 and 100) of amphipathic molecules, which occurs at a well-defined concentration known as the critical micelle concentration.



a particle of the disperse phase of a sol, that is, of a highly disperse colloidal system with a liquid dispersion medium.

Micelles consist of nuclei of crystalline or amorphous structure and of a surface layer containing solvated molecules of the liquid medium. The surface layer of a micelle of a lyophilic sol is formed of adsorbed molecules or ions of a stabilizer. In the case of lyophobic hydrosols stabilized by electrolytes, the nucleus of the micelle is surrounded by two layers of oppositely charged ions (the electric double layer). There is an equal number of positive and negative charges in the electric double layer; the micelle as a whole is therefore electrically neutral.

The ions of the adsorption layer are located directly on the surface of the nucleus. All ions of one of the signs and some of those of the opposite sign (counterions) are part of this layer. The remainder of the counterions form the diffuse layer, which surrounds the micelle as an ionic cloud whose density decreases with increasing distance from the nucleus. The diffuse layer hinders the approach and aggregation (cohesion) of particles in Brownian motion.

In lyophilic sols and colloidal dispersions of the soap hydrosol type (for example, of sodium oleate or potassium lauryl sulfate), the micelles are molecular aggregates. In each molecule a long hydrocarbon (hydrophobic) chain is bound to a polar (hydrophilic) group. In forming the micelle, dozens or even hundreds of molecules aggregate, so that the hydrophobic radicals form the nucleus (inner region) and the hydrophilic groups form the surface layer. If the dispersion medium is an organic liquid, the orientation of the molecules in the micelle may be reversed. The polar groups concentrate in the nucleus, and the hydrophobic radicals are directed toward the external phase.

The simplest structural types of micelles may be diagramed with the micelle-forming molecule represented as a wavy line (hydrophobic chain) with a small circle (hydrophilic group) at the end (see Figure 1).

Figure 1. Basic micelle types

Micelle structures (1) and (2) represent hydrophilic sols; types (3) and (4), organophilic sols. Upon dilution of the system below the critical micelle-formation concentration, spherical micelles (1) and (3) decompose reversibly into separate molecules or dimers. At higher concentrations, they are converted into lamellar micelles, represented by types (2) and (4); these may interact to form a structural gel network within the system.

The detergent action of aqueous solutions (more precisely, of colloidal dispersions) of soaps, as well as certain phenomena in biological systems and technological processes, are explained by the presence of micelles.


References in periodicals archive ?
Since jackfruit seeds are not employed in food industries and since there is a lack of studies on protein extraction from jackfruit seeds by reverse micelles, current research develops an alternative method for protein extraction from jackfruit seed flour using reverse micelles, with sodium dodecyl sulphate (SDS) as surfactant and butanol as organic solvent.
Water insoluble hydrophobic drugs can be encapsulated in amphiphilic PEG-PLA micelles either by physical entrapment method or by covalent chemical conjugation techniques [19].
Blank mixed micelles (B-MM) devoid of curcumin were prepared using similar method.
5]/s for the hydrolysis of bis-[micro]MPPE with micelles of CTABr in buffer solutions.
The casein micelles are sterically stable due to hair like structure of -casein thus considered as polyelectrolyte brush in a medium of high ionic strength.
And targeting of such micelles by attaching ligands for specific receptors could potentially reduce the extent of nonspecific toxicity associated with many drugs [14, 15].
Micellization creates micelle clusters just as bile does, and then embeds them into a bipolar spherical matrix the way bile does.
Based on comparisons of plasma AUC, the study demonstrates significant differences between the three curcumin formulations with total AUG as follows: native curcumin 66 [+ or -]116 nmol/Lxh, curcumin micronisate 583 [+ or -]289 nrnol/Lxh, and curcumin micelle 12148 [+ or -]4547 nmol/Lxh.
These could be interpreted using the kinetic model of the pseudophase proposed by Menger and Portnoy [14], which, taking the micelles as a pseudophase uniformly distributed in the aqueous phase, put forward a reaction scheme with a micelle-substrate equilibrium governed by an equilibrium constant [K.
The special polymers are integrated into the surfactant micelles to give the following effects:
The largest micelles developed to date are in the HM-polymer surfactant, created by linking groups of micelles together using a polymerizing component.