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Related to Microcephaly: macrocephaly


The condition of having an abnormally small head, with a circumference less than two standard deviations below the mean.



substantial reduction in skull and brain size in the presence of normal dimensions of other parts of the body. Microcephaly is accompanied by mental deficiency, from mild imbecility to idiocy. The causes of microcephaly are viral diseases suffered by the mother during the first three months of pregnancy, toxoplasmosis, and, sometimes, intrauterine meningoencephalitis of the fetus. The prognosis is unfavorable.

References in periodicals archive ?
Broder continued, "With no preventative vaccines or curative medicines and now an emerging threat of potentially affiliated ailments to the Zika virus including congenital anomalies such as microcephaly and neurological disorders such as Guillain--Barre syndrome prompting an epidemiological alert from the Pan American Health Organization/World Health Organization last week, effective strategies are required.
Microcephaly may stem from a variety of conditions that cause abnormal growth of the brain during gestation or degenerative processes after birth, all resulting in a small head circumference.
Criteria of the Council of State and Territorial Epidemiologists (2009) met by patient with confirmed case of congenital rubella * Criteria met by Criteria case-patient Clinical criteria Congenital heart disease ([dagger]) Yes Microcephaly Yes Developmental delay Yes Hepatosplenomegaly Yes Purpura No Cataracts/congenital glaucoma No Hearing impairment No Pigmentary retinopathy No Jaundice No Meningoencephalitis No Radiolucent bone disease No Laboratory criteria Demonstration of rubella IgM Yes Persistent rubella antibody in an infant Yes Positive rubella RT-PCR Yes Isolation of rubella virus No * RT-PCR, reverse transcription PCR.
As part of their study, Lancaster, Knoblich and colleagues grew personalized organoids using cells from the skin of a patient with microcephaly caused by mutations in a known gene.
The youngster has a range of chronic disabilities including, microcephaly, global development delay, low white matter and myelin levels in brain, West Syndrome, spasticity, visual impairment, talipes (club foot), strabismus (crossed eyes), face sensitivity, gastroesophageal reflux disease and osteoporosis.
A 2-year-old boy presented with microcephaly and developmental delay.
Ali was born at 35 weeks via emergency Caesarean section and immediately diagnosed with a severe neuro-development disorder called microcephaly.
5 ppb induced structural defects including microcephaly, neural tube defects, and gross craniofacial defects.
They included hydrocephaly and microcephaly, as well as cardiopulmonary, skeletal, and genitourinary malformations.
Sandra Perkins, 66, from Llantwit Major, whose daughter Naomi has microcephaly, cerebral palsy, autism and epilepsy, said: "It is a lifeline for us.
Microcephaly is a condition in which the head of the sufferer is markedly smaller than average.

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