Microglia


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Related to Microglia: Astrocytes, Oligodendrocytes

microglia

[mī′kräg·lē·ə]
(neuroscience)
Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.

Microglia

 

mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
Dendritic spines on neurons, which get input from synapses, similarly withered on the high-fat diet, but like the microglia processes, were restored with the lower-fat fare.
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway.
The researchers found that mice with fewer microglia had weaker connections between neurons, and less cross-talk between different brain regions.
Microglia begin to colonize the rodent brain around E9-E10 (Ginhoux et al.
These agents have direct effect on microglia cells and inhibit mediators of inflammation.
Infections stimulate microglia to produce signaling molecules, called cytokines, which spur a cascade of chemical changes in the brain.
Perhaps equally important will be a better understanding of the roles played by brain microglia in neurodegeneration and neural repair and how to lessen the former two and increase the last.
The US researchers focused on special immune system cells the brain called microglia which engulf, remove and recycle harmful biochemical debris.
The US researchers focused on special immune system cells in the brain called microglia which engulf, remove and recycle harmful biochemical debris.
They found that extracts of blueberries, strawberries and acai berries - a grape-like fruit from the Brazilian rainforest - blocked the action of a protein that stops microglia doing their job.
It is also well recognized that microglia arc reactive in the AD brain.
Duncan and team, who in a series of papers showed the impacts of the antibiotic minocycline on microglia and its potential promise as a therapeutic approach for MS.