Immunosuppression after traumatic or ischaemic CNS damage: it is neuroprotective and illuminates the role of microglial cells
How microglial cells
become weakened in Alzheimer's is not fully understood, Kettenmann says.
At 24 hr after IT DEP administration, immunohistochemical analysis showed that DEP up-regulated IBA-1 on microglial cells
, without obvious differences in morphology or cell number (Figure 3), a response similar to microglial activation previously observed in response to systemic LPS administration (Qin et al.
Moreover, all arimoclomol-treated groups tended to have a reduction in the number of apoptotic cells and microglial cells
compared to controls in the zone surrounding the lesion, again reaching statistical significance (p<0.
Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and proinflammatory cytokine production in murine BV-2 microglial cells
He adds that his team's microglial cell
culture may help test drugs targeted at halting HIV infection in the central nervous system.
2008), reveal that CI/R-induced brain infarction developed along with microglial cell
activation and leukocyte infiltration in the infarct area which occurred in parallel with cerebral lipid peroxidation and protein nitrosylation in the damaged sites, indicating that oxidative and nitrosative stresses elicited by these inflammatory cells did contribute to the infarction.
Overexpression of Grp78 in BV2 mouse microglial cell
lines  and astrocytes protected against ischemic injury and preserved respiratory activity and mitochondrial membrane potential after ischemic stress .
2010)  have shown that HSV-1 induced neural cell oxidative tissue damage and cytotoxicity, which are mediated by microglial cell
through a TLR2-dependent mechanism.
Couez, "Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell
line," Journal of Neuroscience Research, vol.
The hexane fraction of ginger extract and the methanol extract of Ficus religiosa sheet significantly decreased the production of NO, prostaglandin E2, IL-1[beta], IL-6, and TNF[alpha] through the inhibition of MAPK and NF-[kappa]B in BV2 microglial cell
line stimulated with lipopolysaccharide (LPS) [69, 70].
Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-[gamma]1 signaling pathway in murine BV-2 microglial cells