Microglia

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microglia

[mī′kräg·lē·ə]
(neuroscience)
Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.

Microglia

 

mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
Immunosuppression after traumatic or ischaemic CNS damage: it is neuroprotective and illuminates the role of microglial cells.
How microglial cells become weakened in Alzheimer's is not fully understood, Kettenmann says.
At 24 hr after IT DEP administration, immunohistochemical analysis showed that DEP up-regulated IBA-1 on microglial cells, without obvious differences in morphology or cell number (Figure 3), a response similar to microglial activation previously observed in response to systemic LPS administration (Qin et al.
Moreover, all arimoclomol-treated groups tended to have a reduction in the number of apoptotic cells and microglial cells compared to controls in the zone surrounding the lesion, again reaching statistical significance (p<0.
Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and proinflammatory cytokine production in murine BV-2 microglial cells.
He adds that his team's microglial cell culture may help test drugs targeted at halting HIV infection in the central nervous system.
2008), reveal that CI/R-induced brain infarction developed along with microglial cell activation and leukocyte infiltration in the infarct area which occurred in parallel with cerebral lipid peroxidation and protein nitrosylation in the damaged sites, indicating that oxidative and nitrosative stresses elicited by these inflammatory cells did contribute to the infarction.
Overexpression of Grp78 in BV2 mouse microglial cell lines [102] and astrocytes protected against ischemic injury and preserved respiratory activity and mitochondrial membrane potential after ischemic stress [103].
2010) [172] have shown that HSV-1 induced neural cell oxidative tissue damage and cytotoxicity, which are mediated by microglial cell through a TLR2-dependent mechanism.
Couez, "Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line," Journal of Neuroscience Research, vol.
The hexane fraction of ginger extract and the methanol extract of Ficus religiosa sheet significantly decreased the production of NO, prostaglandin E2, IL-1[beta], IL-6, and TNF[alpha] through the inhibition of MAPK and NF-[kappa]B in BV2 microglial cell line stimulated with lipopolysaccharide (LPS) [69, 70].
Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-[gamma]1 signaling pathway in murine BV-2 microglial cells.