Microglia

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microglia

[mī′kräg·lē·ə]
(neuroscience)
Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.

Microglia

 

mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
Immunosuppression after traumatic or ischaemic CNS damage: it is neuroprotective and illuminates the role of microglial cells.
Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-[kappa]B activation and ERK phosphorylation.
The data reported at AAIC demonstrates the potential of new target structures -- such as cannabinoid type 2, P2X7 and COX2 receptors -- to more accurately reflect various stages or types of the microglial cells, telling us if they're being destructive or protective," said Jacobs.
Microglial cells, the nervous system's defenders, are unable to eliminate this substance, which forms deposits called senile plaques.
Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain.
Microglial cells are the brain's first and primary immune defense.
The surrounding tissue was gliotic and contained a mixed inflammatory infiltrate including perivascular lymphocytes and plasma cells as well as microglial cells with loose microglial nodule formation (Figure 3).
Pro-inflammatory cytokines can penetrate the blood-brain barrier and affect those microglial cells located in specific areas of the brain involved in mood regulation and reward process.
A biopsy specimen of the pontine lesion in December 2010 showed a reactive, T-cell-predominant, CD3-positive, lymphocytic infiltrate with scattered macrophages and microglial cells with few plasma cells (Figures 2A, B and 3A, B).
Within the cerebellum and piriform plexus, diffuse mild vacuolation of the grey and white matter was present along with mildly increased numbers of microglial cells.
Its innovative line of research is to control the activity of microglial cells involved in a wide range of diseases related to brain inflamation or acute cerebral damage.