Microglia

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Related to Microglial cells: Astrocytes

microglia

[mī′kräg·lē·ə]
(neuroscience)
Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.

Microglia

 

mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
A) Fibronectin increases after nerve injury and binds to [alpha]5[beta]1 integrin on microglial cells, resulting in the activation of the phosphatidylinositol 3kinase (PI3K)-Akt and mitogen-activated protein kinase (MAPK) kinase-extracellular signal-regulated kinase (MEK-ERK) signaling cascades through the action of the tyrosine kinase Lyn.
After exposure to C20, animals had a significantly lower mean total microglial number than that in controls (T0; Figure 4), and the proportion of activated microglial cells was significantly higher than in controls at T0 and T1, but it was comparable to controls by T56 (Figure 3).
Caption: In this 3-D reconstruction, a microglial cell (red) engulfs synapses (green) in a mouse's hippocampus after an injection of the Alzheimer's-related protein amyloid-beta.
Lokensgard, "Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2," Journal of Neuroinflammation, vol.
Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus.
Moreover, as HIV-1 disease advances there is a reduction in CD4 + cells and there is a selection towards macrophage tropic isolates of HIV-1 that further infect the brain: essentially the brain cells that are of macrophage lineage namely the microglial cells.
Neurotensin and the neurotensin receptor-3 in microglial cells.
T cells and B cells in the CNS, reactivation by resident antigen presenting microglial cells, secretion of proinflammatory cytokines/chemokines along with generation of other inflammatory mediators.
In a recent study, fluoxetine was added to LPS-stimulated microglial cells.
We knew that in embryonic development, some blood cells do go to the brain and become microglial cells," said Chan.
Microglial cells, the nervous system's defenders, are unable to eliminate this substance, which forms deposits called senile plaques.
Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain.