Microsome

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Related to Microsomes: Signal recognition particle, signal peptidase

microsome

[′mī·krə‚sōm]
(cell and molecular biology)
A fragment of the endoplasmic reticulum.
A minute granule of protoplasm.

Microsome

 

a fragment in the endoplasmic network (bubbles about 1,000 angstroms diameter), formed when cells are destroyed during the homogenization of animal and plant tissues. The microsome fraction of the homogenate is isolated by differential centrifugation. There are two types of microsomes: smooth-surfaced and rough-surfaced (as a result of the distribution of ribosomes on the latter). Before the technique of separating cellular homogenates was perfected, the microsome fraction also included mitochondria.

References in periodicals archive ?
Metabolism of N,N-diethyl-meta-toluamide by rat liver microsomes.
The effect of gene polymorphisms on SRL metabolism was investigated in vitro using human liver microsomes, and potential associations with SRL blood concentrations and AEs were explored in parallel in 113 kidney transplant recipients.
arjuna on superoxide anions hydroxyl radicals and lipid peroxidation in Microsomes.
Non-enzimatic lipid peroxidation of microsomes and mitochondria isolated from liver and heart of pigeon and rat.
The effects of DMHBR on gastric proton pump (H+, K+-ATPase) activity: The influence of DMHBR and omeprazole on the H+, K+-ATPase isolated from albino rat gastric microsomes as compared with the control group.
At the same time, it was also explored the structure-activity relationship of MA and OA with CYP activity in human liver microsomes.
For kinetic studies, CYP2B6 and pooled human liver microsomes (HLMs) were incubated with BDE-47 (0-60 [mu]M).
Inhibitory effects of flavonoids rutin and quercetin on ferrous ion-dependent lipid peroxidation of lecithin liposomes and NADPH-and CCl4-dependent lipid peroxidation in rat liver microsomes were studied to elucidate the chelating and free radical scavenging activities of these compounds.
Using ideal drug concentrations and incubation conditions identified as part of the study, they incubated pooled human CYP3A4 microsomes with 17P alone and with each of the 25 medications known to be substrates and or inhibitors of CYP3A4.
The metabolism of capsaicin has been found to be similar in human, rat, and dog microsomes (26).
1981) first reported the purification of [DELTA]-9 desaturase in rat liver microsomes.