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Related to Mineralocorticoids: Glucocorticoids



hormones of the adrenal cortex that belong to the corticosteroid group and affect mainly the exchange of Na+ and K+ ions in an organism. Human adrenal glands secrete 0.15–0.4 mg daily of aldosterone, the principal mineralocorticoid. Another mineralocorticoid, desoxycorticosterone, is an intermediate product of the biosynthesis of corticosterone and possibly of aldosterone. Mineralocorticosteroids regulate the elimination of electrolytes by the kidneys, thereby promoting the reabsorption of Na+ by the renal tubules and reducing the reabsorption of K+.

An excess of mineralocorticosteroids leads to an increase of Na+ in the blood, which causes water retention and edema. An insufficiency of mineralocorticosteroids leads to the increased elimination of Na+ with the urine, causing increased excretion of water and tissue dehydration.


Bersin, T. Biokhimiia gormonov. Moscow, 1964. (Translated from German.)
Glaz, E., and P. Vecsei. Aldosterone. Oxford, 1971.
References in periodicals archive ?
The circulating aldosterone, whose classical targets are kidney epithelium, colon and salivary glands, overpasses the plasma membrane of such tissues and binds to the cytoplasmic mineralocorticoid receptor.
The resultant decline in cortisol and its feedback inhibition on pituitary ACTH will lead to an increase in ACTH release in order to bring cortisol production to normal levels and so leading to overstimulation of the steroid synthetic pathway at the expense of excess formation and accumulation of steroid precursors prior to the enzymatic block of 17[alpha]-hydroxylase and their products, particularly mineralocorticoids precursors (11-deoxycorticosterone and corticosterone), as well as hyperplasia of the adrenal cortex.
Typical Addison's, often called primary Addison's, is caused by adrenal dysfunction that creates both glucocorti-coid and mineralocorticoid deficiencies.
The synthetic glucocorticoids are classified by their anti-inflammatory power, half life, and mineralocorticoid effect; they operate in almost every cell through genomic and non genomic mechanisms of action producing different responses.
Addison's disease (named after the 19th century British physician who first described the condition in humans) is a comparatively rare feline disorder marked by the inadequate secretion of glucocorticoids and, in some cases, mineralocorticoids as well.
In addition, diverse contraindications, restrictions of application, interactions, and at times significant adverse reactions must be taken into account for instance in the drug treatment with mineralocorticoids or sympathomimetics.
These may be traced to use of laxatives, diuretics, mineralocorticoids, amphotericin B, or lithium.
Surgery usually is preferred in patients with incidentalomas and excess levels of glucocorticoids, mineralocorticoids, adrenal sex hormones, or catecholamines.
We have also demonstrated that steroid synthesis and secretion of both mineralocorticoids and glucocorticoids can be studied in adrenal slice cultures.
Aldosterone belongs to a class of hormones called mineralocorticoids, also produced by the adrenal glands.
Thus, selective hydroxylase inhibition causes build-up of progestogens and mineralocorticoids and reduction in cortisol levels in CRPC patients, resulting in secondary mineralocorticoid excess (ME), a clinical syndrome including edema, hypokalemia and hypertension.