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mitochondrion |
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mitochondrion a small spherical or rodlike body, bounded by a double membrane, in the cytoplasm of most cells: contains enzymes responsible for energy production How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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As its name implies, the intrinsic apoptotic pathway begins within the cell, when toxic alterations bring about a decrease in mitochondrial transmembrane potential, leading to the opening of mitochondrial membrane pores and the release of cytochrome C and other substances into the cytoplasm. The cytotoxic potential of arsenic trioxide leads to decreased mitochondrial membrane potential, fragmented DNA, and finally to apoptotic cell death. CPT and HOAD are mitochondrial enzymes that participate in the transportation of fatty acids through the mitochondrial membrane and in the beta oxidation of fatty acids in the mitochondrial matrix, respectively. |
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