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mitogen-activated protein kinases

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mitogen-activated protein kinases [‚mīd·ə·jən ¦ak·tə‚vād·əd ¦prō‚tēn ′kī‚nās·əs]
(cell and molecular biology)
A large kinase network in which upstream kinases activate downstream kinases that, in response to phosphorylation, translocate to the nucleus and activate transcription factors. Abbreviated MAPKs.
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Polyphenols up- or down-regulated activity of a number of key enzymes, including mitogen-activated protein kinases and protein kinase C, and increased or decreased protein/mRNA levels, including that of cyclins, oncogenes, and tumor suppressor genes.
Mechanisms of cancer prevention by green and black tea polyphenols by Life Extension
Over the period of five weeks, the researchers found that cigarette smoke turned on enzymes called mitogen-activated protein kinases linked to cell growth and survival in heart muscle.
Prolonged exposure to cigarette smoke can alter shape of heart by Asian News International
Therefore, its important roles for above diseased status are to respond to various external stimuli which have been shown to relate to the activation of mitogen-activated protein kinases (MAPKs) and other transcription factors (Kyriakis, 1999; Schmidt et al.
Suppression of tissue necrosis factor-alpha or hydrogen ... by Tsao, Tien-Ping; Lai, Jenn-Haung; Yang, Shih-Ping; Ho, Ling-Jun; Liou, Jun-Ting; Cheng, Cheng-Chung; / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
 
 
 
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