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mitomycin
(redirected from Mitomycin C)

   Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia 0.01 sec.
mitomycin [¦mīd·ə¦mīs·ən]
(microbiology)
A complex of three antibiotics (mitomycin A, B, and C) produced byStreptomyces caespitosus.


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The HCSE inhibited the genotoxicities of furylfuramide, N-methyl-N-nitrosourea, methyl methanesulfonate, mitomycin C, 2-aminoanthracene and aflatoxin B1 at a concentration of 1 mg/ml or more.
The drug called MMC - mitomycin C - is used mainly against bladder and bowel tumours and is activated by natural human enzymes, but its use is limited by severe side effects at high doses.
Since the report by Iyer and Szybalski (1964), the requirement for redox biotransformation of mitomycin C (MMC) has been well recognized in pharmacology, because MMC must be activated by a series of redox reactions leading to semiquinone derivatives coupled with ROS formation (Dusre et al.
 
 
 
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