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episode |
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episode 1. an incident, sequence, or scene that forms part of a narrative but may be a digression from the main story 2. (in ancient Greek tragedy) a section between two choric songs 3. Music a contrasting section between statements of the subject, as in a fugue or rondo episode [′ep·ə‚sōd] (geology) A distinctive event or series of events in the geologic history of a region or feature. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| In the first randomized double-blind comparison of the efficacy and safety of Zyprexa and lithium in the prevention of bipolar episode relapse, patients diagnosed with bipolar I disorder, who had at least two manic or mixed episodes within six years and a YMRS total score greater than or equal to 20, received open label combination therapy of Zyprexa and lithium for six to 12 weeks. The FDA approval is based on data from two double-blind, randomized, placebo-controlled trials which showed that bipolar patients in manic or mixed episodes, treated with Zyprexa in combination therapy, demonstrated improved manic and depressive symptoms when compared to patients treated only with lithium or valproate alone. Patients were eligible if they had moderate to severe bipolar I disorder with depression as measured by a baseline MADRS (Montgomery-Asberg Depression Rating Scale) rating greater than or equal to 20 and one previous manic or mixed episode serious enough to warrant treatment with a mood stabilizer or antipsychotic. |
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