Hunter syndrome

(redirected from Mucopolysaccharidosis Type II)
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Hunter syndrome

[′hənt·ər ‚sin‚drōm]
(medicine)
An X-linked recessive disease in which a deficiency of the enzyme iduronate sulfatase leads to the accumulation of mucopolysaccharides in various body tissues, resulting in developmental abnormalities, skeletal deformations, mental retardation, and, in severe cases, early death. Also known as mucopolysaccharidosis II.
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About Hunter Syndrome Hunter syndrome, also known as mucopolysaccharidosis type II, or MPS II, is a lysosomal storage disorder caused by inadequate activity of the enzyme iduronate-2-sulfatase (IDS), which is needed to break down complex sugars produced by the body.
Cervical myelopathy in mucopolysaccharidosis type II (Hunter's Syndrome).
4] Nonstandard abbreviations: MPSIH, mucopolysaccharidosis type I (Hurler syndrome); MPS II, mucopolysaccharidosis type II (Hunter disease); GAG, glycosaminoglycan; HCT, hematopoietic stem cell transplantation; ERT, enzyme replacement therapy; BBB, blood-brain barrier; LSD, lysosomal storage disease; ESI, electrospray ionization; CSF, cerebrospinal fluid; DS, dermatan sulfate; HS, heparan sulfate; CS, chondroitin sulfate; UPLC, ultra-performance liquid chromatography; IT, intrathecal; IV, intravenous; IRB, institutional review board; SRM, selected reaction monitoring; m/z, mass-to-charge ratio; CID, collision-induced dissociation.
Joe has Mucopolysaccharidosis type II, which causes hearing loss, joint stiffness and difficulty in breathing.
He has a condition known as Mucopolysaccharidosis type II, which causes hearing loss, joint stiffness and difficulty in breathing.

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