Multipotential Stem Cells

Multipotential Stem Cells

 

cells making up the continually self-renewing tissues of both adult and developing animals. In vertebrates they are found, for example, in epithelial, hemopoietic, and bony tissues. Each tissue has characteristic multipotential stem cells, distinguished by their proliferative activity and degree of specialization. Differentiated tissue cells often have common multipotential stem cells, which can develop in different directions. For example, in mammalian hemopoietic tissue, various blood cells—erythrocytes, thrombocytes, and leukocytes—are formed from common multipotential stem cells. The perpetual presence of these stem cells in an organism ensures not only the renewal of the cell population of the corresponding tissues under normal conditions, but also the replenishing of cells when they are destroyed.

REFERENCE

Zavarzin, A. A. Ocherki evoliutsionnoi gistologii krovi i soedinitel’noi tkani: Izbr. trudy, vol. 4. Moscow-Leningrad, 1953.
References in periodicals archive ?
Transplantation of multipotential stem cells in patients with MS is a relatively safe procedure and induces immediate immunomodulatory effects.
Recently, it has been postulated that the hematogenous spread of multipotential stem cells occurs with eventual infiltration of various tissues and organs.
2) EMH has been suggested to result from hematogenous spread of multipotential stem cells, with their being filtered out of the blood in various organs and tissues.
Multipotential stem cells are derived from pluripotential stem cells and can be found in adults.
Examples of research areas appropriate to this PA include, but are not limited to, projects to 1) expand the number of nonhuman animal model systems in which embryonic stem cells are available; 2) identify, isolate, culture, and characterize multipotent stem cell populations derived from nonhuman embryonic stem cells; 3) identify, isolate, culture, and characterize multipotent stem cells from postfetal tissue types; 4) generate and use panels of markers for stem cell attributes common across species for use in characterization and isolation of stem cells in a range of animal species or tissues; and 5) create universal methods of culture to maintain the undifferentiated state of embryonic or other characterized multipotential stem cells across nonhuman animal species.
The recombinant BMP-2 has proliferative effects on the multipotential stem cells toward the fibroblastic, osteoblast/osteocyte, and adipocyte cell lines (Yamaguchi et al, 1991 and Sigurdsson et al, 1995).
Pittenger led efforts in the isolation, characterization, and differentiation of the multipotential stem cells found in adult bone marrow commonly know as mesenchymal stem cells (MSCs).
5,6) Recently, it has been postulated that hematogenous spread of multipotential stem cells occurs with eventual infiltration of various tissues and organs.
These surprising results lend a new perspective to stem cell differentiation and suggest that multipotential stem cells may express a wide variety of genes at low levels and that stem cells achieve their remarkable plasticity by downregulating the expression of many of these background genes.