Mutation Pressure


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Mutation Pressure

 

a factor that tends to decrease the average fitness of populations because of the continuous appearance of injurious hereditary changes. The mutation pressure contributes to the general genetic load of deleterious genes in a population. Besides being influenced by the mutation pressure, the fitness of populations is affected by immigration from neighboring populations of individuals with genotypes less suited to the new conditions than the indigenous inhabitants, dissimilar fitness of homozygotes and heterozygotes, and other factors.

REFERENCE

Muller, H. J. “Our Load of Mutations.” American Journal of Human Genetics, 1950, vol. 2, p. 111.