genetic load

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genetic load

[jə¦ned·ik ′lōd]
(genetics)
The reduction in fitness of a diploid population due to new mutant genes and those already in the gene pool.
References in periodicals archive ?
To determine whether the cancer mutation load is correlated with the expression levels of NEIL1, NEIL2, and NEIL3 in human cancer, mRNA expression data and somatic mutation data for 13 cancer types were obtained from the TCGA database.
The prognosis of MELAS patients depends on the location of genetic mutations, mutation load, and the onset of disease and interventions.
We developed a method to accurately quantify the mutant load in mtDNA; using this quantitative DHPLC analysis method, we measured the levels of heteroplasmy in several DNA samples with known mutation loads.
Under the mutational accumulation model, sexual populations gain an advantage over asexual populations due to the efficiency of recombination in reducing the population mutation load.
We ran computer simulations of this model for populations with specified mating systems (proportions of selfing, outcrossing, and asexuality), to characterize equilibrium mutation load and inbreeding depression under different mating systems.
Whether or not deleterious mutations interact in affecting fitness can have important consequences for the mutation load of a population (Kimura 1961; Kimura and Maruyama 1966), and for the advantage that sex and recombination can provide to reduce this load (Crow 1970; Kondrashov 1982).
Following the classic Haldane principle (1937), the population genomic mutation load only depends on the fitness mutation rate.
I also calculated and recorded average number of deleterious mutations carried in adult plants (after selection) by genotype at the special locus (AA, Aa, aa), average number of deleterious mutations by gamete type (A, a), and overall mutation load and inbreeding depression every 20 generations during the course of each run.
1963) have shown that the extent to which drift causes the expressed mutation load to increase is a function of s, the selective disadvantage of a mutation.
The proportion of a population that does not reproduce because of selection against mutations is the mutation load L.
The population size was kept constant by allowing adults to produce more and more progeny as the mutation load for viability increased.