genetic load

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genetic load

[jə¦ned·ik ′lōd]
(genetics)
The reduction in fitness of a diploid population due to new mutant genes and those already in the gene pool.
References in periodicals archive ?
On the basis of these observations, we developed a quantitative DHPLC method to study mtDNA mutation load.
Highlights: High frequency testing of circulating tumor (ct)DNA mutations in patients receiving molecularly targeted therapies can be used to determine early changes in mutation load brought about by treatment administration, in addition to tumor dynamics when used to monitor treatment response longitudinally
These utilities include the ability to determine response to therapy, identify disease progression earlier than cancer imaging, monitor for minimal residual disease after surgery, stratify patients according to baseline mutation load, and act as an alternative to invasive and costly biopsy procedures.
With cancer mutations occurring in relatively low abundance, a key challenge is obtaining enough sample material to accurately detect and track ctDNA mutation load over time.
Published study results in the 2014 ASCO Annual Meeting Proceedings demonstrating that oncogene mutation load in urinary cell-free DNA is significantly correlated with treatment response