genetic load

(redirected from Mutational load)
Also found in: Dictionary, Medical.
Related to Mutational load: Genetic burden

genetic load

[jə¦ned·ik ′lōd]
(genetics)
The reduction in fitness of a diploid population due to new mutant genes and those already in the gene pool.
References in periodicals archive ?
As predicted by Williams, trees have larger mutational loads than most animals (cf.
In contrast, the KRAS mutational load in chronic pancreatitis was 6.
Williams' (1975) Elm-Oyster evolutionary model and experimental evidence for a high mutational load.
Initial results demonstrated that immediate changes in EGFR mutational load using a urine specimen may identify patients who respond to anti-EGFR therapy much earlier than with follow-up CT-scans.
Edison Liu: First will be the conceptual advance in understanding the detailed genetic mutations and mutational load of human cancers.