Because the mice did not express Lkb1 in myelin forming glial cells, this allowed scientists to analyze its role in glial cell metabolism and formation of the myelin sheath
Plus, say the scientists, these tiny tubes resemble myelin sheaths
, which surround and protect neuron extensions in living organisms.
Polar capping of immunoglobulin G (IgG) on macrophages engaged in active myelin phagocytosis; (13) the presence of large numbers of plasma cells in subacute plaques; the identification of immunoglobulin and complement products on degenerating myelin sheaths
in acute lesions; (14,15) and, most recently, evidence of dramatic clinical and radiological efficacy of the monoclonal antiCD20 antibody, rituximab, in relapsing MS (16) support the notion that humoral factors play an important role in the immunogenesis of the disease.
In MS, the patients' immune systems turn on their own central nervous systems, stripping the protective myelin sheaths
from nerve fibers and leading to problems with vision, balance, and coordination.
The nerves or neurones are the wiring and the myelin sheath
is the plastic coat around them.
MCT-125 targets fatigue associated with MS, an autoimmune disease in which immune cells attack and destroy the myelin sheath
protecting neurons in the brain and spinal cord.
The money is going to a Cambridge University research project which aims to find a way of repairing the central nervous system's myelin sheath
, that is damaged when MS is contracted.
But the overdose also ate away at the myelin sheath
that protects the spinal cord.
I have multiple system's atrophy, one of the illnesses which directly attacks the myelin sheath
of the brain and central nervous system.
In this disorder the antibodies destroy the myelin sheath
that surrounds the peripheral motor neurons and cause inflammation of the axons of the affected nerve cells.
In particular, differences were marked in genes involved in compaction and maintenance of the myelin sheath
, and in aptosis and survival of oligodendrocytes.
Waxman's early research showed that when the axon's protective myelin sheath
is damaged, as happens in MS, the exposed parts of the axon don't contain enough sodium channels to power nerve conduction.