This calming effect may extend to immune cells targeting central nervous system proteins besides myelin basic protein
But the researchers were surprised when viruses lacking the myelin basic protein
also triggered the disease.
Myelin basic protein
in the cerebrospinal fluid of patients with brain tumors.
Segal's group further found that severe to moderate autoimmune disease results if the cells that react to myelin basic protein
are exposed to bacterial DNA or the cell wall component and are then injected into mice.
Radioimmunoassay of myelin basic protein
in spinal fluid: an index of active demyelination.
All clones were specific for S100B and did not cross-react with S100A1, neuron-specific enolase-[gamma][gamma], neuron-specific enolase-[alpha][alpha], myelin basic protein
, and synapsin-1.
They began by "gluing" the B chain to myelin basic protein
, a material that sheathes nerves and falls under immune attack in multiple sclerosis (MS).
7] evaluated the value of neuron-specific enolase, S-100 protein, and myelin basic protein
in CSF in patients who underwent a diagnostic lumbar puncture for a clinical indication such as CNS infection or another neurological disorder.
The Einstein group theorized that injecting a preparation containing two components of myelin -- myelin basic protein
and galactocerebroside -- might elicit a myelin-restoring immune response in guinea pigs with already established disease.
BHT-3009 is an antigen-specific plasmid encoding myelin basic protein
(MBP) currently being evaluated for the treatment of multiple sclerosis (MS).
Many scientists believe myelin basic protein
, or MBP, may be one of several of the targets of immune attacks in MS.
New research shows that people with multiple sclerosis (MS) have immune cells that react with myelin basic protein
, a key component of the protective sheaths surrounding nerve fibers in the brain and spinal cord.