Several groups worldwide are developing vaccines using pieces of myelin proteins
, or peptides--which are targets for immune T cells--to induce immunity to the MS attack by these cells.
In vivo detection of myelin proteins
in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology.
Additionally, the immunology data shows that reactivity to all three of the key myelin proteins
(MOG, PLP and MBP) was broadly present in study patients, which may be an important finding for the future treatment of MS.
Stephen Miller, PhD, and his team at Northwestern University Feinberg School of Medicine in Chicago, have shown that mice with an MS-like disease called EAE have fewer relapses when they are treated with a mixture of small bits of myelin proteins
and signal cells programmed to suspend T cell activation.
EAE is induced by immunization with myelin, myelin proteins
, and myelin protein
encephalitogenic epitopes or by the passive transfer of myelin-reactive cluster of differentiation (CD) 4 cells.
In relapsing-remitting MS, the body's immune system attacks the myelin proteins
surrounding the nerves.