2006) Major myelin protein
gene (P0) mutation causes a novel form of axonal degeneration.
The team selected seven peptides of myelin proteins
to which T cells have shown high reactivity in MS.
Of prominent myelin proteins
, only PLP family members are present in Ciona
Two families present mutations in the myelin protein
zero gene (MPZ).
This was measured using Opexa's proprietary Epitope Analysis Assay (EAA) which assessed reactivity across all three key myelin proteins
at several time points throughout the 52-week study.
Myelin basic protein, a dominant myelin protein
, is selectively synthesized in these sites, for unlike other myelin proteins
, MBP enters myelin within minutes of its synthesis.
It's possible that each person with MS has T-cells that recognize different myelin proteins
Patient-specific MRTCs are expanded in culture with specific peptides identified by assaying peripheral blood mononuclear cell reactivity against peptides derived from the three myelin proteins
The EAA measures proliferative responses of patient peripheral T-cells upon exposure to peptides of myelin proteins
The reduction in autoantibodies targeting multiple myelin proteins
indicates that BHT-3009 may produce a broad response in a heterogeneous population of MS patients.
We are delighted with the demonstration of tolerization of the immune system to myelin proteins
in individuals with multiple sclerosis.
Steinman and his team have designed customized "cocktails" of the DNA that instruct a number of the relevant myelin proteins
involved in such B cell responses to the disease.