They found that taking any dose of NSAIDs
, including ibuprofen and naproxen, for a week, a month or more than a month was associated with a greater heart attack risk.
Studies suggest NSAIDs
may interfere with aspirins ability to prevent clots and heart attacks.
It found that people who had taken any NSAID
in the previous 14 days had a 19% increased risk of hospital admission for heart failure compared to those who had used NSAIDs
at any point in the past.
It's been well-known for a number of years that newer types of NSAIDs
-- what are known as COX-2 inhibitors, increase the risk of heart attacks.
After examining the data of over 30,000 patients with high blood pressure, researchers at the Institute of Population Health Sciences, National Health Research Institutes in Zhunan, Taiwan, found that those who'd been taking NSAIDs
for at least three months were 32% more likely to have chronic kidney disease than those who didn't take NSAIDs
In addition to the overall increased cardiovascular risk, taking NSAIDs
puts patients at a higher risk of kidney damage, water retention, heart failure, and bleeding, especially gastrointestinal bleeding.
There's significant risk associated with using NSAIDs
, especially on a long-term basis," says Evan Peck, MD, a Cleveland Clinic Florida sports medicine specialist.
provide medical benefits, but they are well known to affect the gastrointestinal tract, kidneys, liver, and cardiovascular system adversely.
The new wording will also note that although newer information may suggest that the risk for heart attack or stroke is not the same for all NSAIDs
, it "is not sufficient for us to determine that the risk of any particular NSAID
is definitely higher or lower than that of any other particular NSAID
The meeting panelists also voted 16-9 that there were not enough data to suggest that naproxen presented a substantially lower risk of CV events than did either ibuprofen or selective NSAIDs
, such as cyclooxygenase-2 inhibitors.
are the most widely used treatment for pain and inflammation in the United States.
The most popular NSAIDs
exert their effects through systemic cyclooxygenase (COX) inhibition, thereby reducing the amount of inflammation-causing prostaglandins produced by the body.