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Related to Necrobiosis: necrobiosis lipoidica diabeticorum


Death of a cell or group of cells under either normal or pathologic conditions.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

References in periodicals archive ?
El sindrome de Sweet, el eritema indurado de Bazin y la necrobiosis lipoidica (que se presentan con granulomas) se consideran diagnosticos diferenciales histologicos (2).
Necrobiosis lipoidica (NL) is another necrobiotic disorder with lesions occurring mainly over legs but can involve other sites as well and is seen in 0.
Histology is characteristic with histiocytes arranged in palisade around central necrobiosis.
Macaron NC, Cohen C, Chen SC, Arbiser JL: gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum.
Localized granuloma annulare must be differentiated from the most common annular lesion, tinea corporis, as well as other annular lesions, including necrobiosis lipoidica and erythema migrans.
Patients presenting necrobiosis lipoidia, in which thermal sensation may be altered, (43) was not evaluated in the present study nor were comparisons WPT, CPT and WCPI with other diagnostic methods.
3% of patients with necrobiosis develop diabetes mellitus.
Biopsies showed the characteristic histologic features of this disorder: a dense nodular granulomatous infiltrate with bizarre, foreign-body type giant cells and Touton giant cells surrounding areas of hyaline necrobiosis of collagen and cholesterol clefts.
Most frequently observed skin disease was bacterial infections (26%), followed by fungal infections (22%), acanthosis nigricans (20%), diabetic foot (16%), nail changes (16%), acrochordons (10%), diabetic dermopathy (9%), necrobiosis lipoidica (9%), viral infections (8%) pruritus (8%) and xanthelasma (8%).
For ulcerative lesions of PG, frequent differential diagnosis include infective such as necrotizing fascitis, vascular occlusive or venous disease, necrobiosis lipoidica, livedoid vasculitis, sarcoidosis, or cutaneous malignancies such as squamous cell carcinoma and basal cell carcinoma, vasculitic processes such as Wegener's, malignancy such as lymphoma or leukemia, and pustular drug reactions.
10,21) Necrobiosis consisting of collagen degeneration accompanied by granulomatous inflammation has also been reported as a rare feature of MCD.