neural crest

neural crest [′nu̇r·əl ′krest]

(embryology)

Ectoderm composing the primordium of the cranial, spinal, and autonomic ganglia and adrenal medulla, located on either side of the neural tube.

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Neural crest

A strip of ectodermal material in the early vertebrate embryo inserted between the prospective neural plate and epidermis. After closure of the neural tube the crest cells migrate into the body and give rise to parts of the neural system: the main part of the visceral cranium, the mesenchyme, the chromaffin cells, and pigment cells. The true nature of the neural crest eluded recognition for many years because this primary organ has a temporary existence; its cells and derivatives are difficult to analyze when dispersed throughout the body. The fact that mesenchyme arises from this ectodermal organ was directly contrary to the doctrine of the specificity of the germ layers.

Neural crest no doubt exists, with similar qualities, in all vertebrate groups, including the cyclostomes. It has been most thoroughly studied in amphibians and the chick. See Germ layers