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neurofibrillary tangle |
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neurofibrillary tangle [‚nu̇·rō‚fīb·rə‚ler·ē ′taŋ·gəl] (pathology) The accumulation of twisted protein filaments (neurofibrils) within neurons of the cerebral cortex; a characteristic pathological feature found in the brains of Alzheimer's disease patients. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Neuropathological alterations involved neuronal loss and neurofibrillary tangles in the basal ganglia, brain stem, and cerebellum. Today, he says, it's most likely that there are two primary causes of dementia: an Alzheimer's disease type "pathology," represented by the neurofibrillary tangles and senile plaques of the disease, and vascular dementia, resulting from significant changes in blood vessels in the brain. Neurofibrillary tangles are the second hallmark of Alzheimer's. |
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