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neurofibrillary tangle

   Also found in: Medical, Wikipedia 0.01 sec.
neurofibrillary tangle [‚nu̇·rō‚fīb·rə‚ler·ē ′taŋ·gəl]
(pathology)
The accumulation of twisted protein filaments (neurofibrils) within neurons of the cerebral cortex; a characteristic pathological feature found in the brains of Alzheimer's disease patients.
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From the point of view of treating Alzheimer's disease, if we can express the mouse gene in human brain cells, we may be able to control the buildup of amyloid beta and tau neurofibrillary tangles.
Novel mouse gene could lead to new Alzheimer's treatments by Asian News International
The plaques, along with neurofibrillary tangles, are thought to contribute to the degradation of the wiring in brain cells and lead to the symptoms of Alzheimer's disease.
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Neurofibrillary tangles, insoluble twisted fibers that build up inside neurons, are like power lines getting crossed up and sending energy to the wrong location.
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