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Related to Neurofibromatosis: Neurofibromatosis Type 2, Neurofibromatosis Type 1


A hereditary disease characterized by the presence of neurofibromas in the skin or along the pathway of peripheral nerves. Also known as fibroma molluscum; multiple neurofibroma; multiple neurofibromatosis; neurinomatosis; neuroblastomatosis; Smith-Recklinghausen's disease.



a disease characterized by multiple tumors of the nerve trunks. It is also called Recklinghausen’s disease after the German pathologist F. Recklinghausen (1833–1910), who first described the disease in 1882.

Neurofibromatosis usually arises in the nerves of the skin, bones, and endocrine glands. It is believed that neurofibromatosis occurs because of a disturbance in the development of the ectodermal germ layer in the embryo; however, the causes and developmental mechanisms of the disease have not been elucidated. Multiple soft tumors of various sizes appear on or within the skin. The tumors are covered with yellow to dark brown pigmentation spots of various sizes. Changes in the bone structure can arise in neurofibromatosis, and the spine can be deformed even to the point of curving. Neurofibromatosis may also affect the central nervous system; in such cases, physical and mental underdevelopment are sometimes observed.

References in periodicals archive ?
Since neurofibromatosis is a genetic condition, Rachael and Mike are concerned that it could have been passed on to one of their children but say Rachael's experiences mean she is perfectly placed to help them live happy and healthy lives.
Secondary Knee Osteoarthritis due to Neurofibromatosis Type 1 Treated with above the Knee Amputation: A Case Report.
En los casos presentados observamos los VS localizados en el angulo pontocerebeloso de forma bilateral, ademas de la region cervical dependientes del nervio espinal; asociados a Neurofibromatosis tipo 2; el cual es un desorden autosomico dominante con una incidencia de 1 en 25-33.
Neurofibromatosis type 1 in childhood (international review of child neurology series).
1989) the significance of MRI abnormalities in children with neurofibromatosis.
Ellis, "Paraparesis after posterior spinal fusion in neurofibromatosis secondary to rib displacement: case report and literature review," Journal of Pediatric Orthopaedics, vol.
Spinal anesthesia for emergency cesarean section in a preeclampsia patient diagnosed with type 1 neurofibromatosis.
Neurofibromatosis Type 1 (von Recklinghausen's disease) in Pregnancy: cesarean delivery outcomes - case report.
Since Neurofibromatosis is has something to do with the genes, if a parent has it, there is a 50% probability that children would develop the disease as well.
Keywords: Pheochromocytoma, Cardiomyopathy, Neurofibromatosis, Hypertension.
Neurofibromatosis sufferer and flirt Justin hasn't hooked up with anyone.