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Any disease affecting neurons.



a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.


Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.


References in periodicals archive ?
These age-related changes may predispose individuals to degenerative disease related to neuropathic pain, and diagnosis is important to establish a proper treatment regimen.
The aim of this investigation was to describe the characteristics of neuropathic pain in treated leprosy patients in a tertiary care referral centre in the metropolitan region of Rio de Janeiro, Brazil.
According to the company, Proclaim DRG Neurostimulation System provides patients with chronic neuropathic pain access to its Proclaim platform, a magnetic resonance (MR)-conditional recharge-free system offering best-in-class programming, upgradeability and increased battery capacity.
In preclinical studies, LX9211 has shown robust efficacy in models of neuropathic pain and is well-tolerated at and above efficacious doses in animals.
The report reviews pipeline therapeutics for Diabetic Neuropathic Pain by companies and universities/research institutes based on information derived from company and industry-specific sources
In contrast, neuropathic pain does not serve a protective function and is not self-limiting.
The rats subjected to the neuropathic pain model developed robust behavioral allodynia after SNL, which persisted for at least 2 weeks.
This issue may raise the possibility of a sympathetically mediated component to neuropathic pain conditions.
Keywords: Neurological level of injury, Neuropathic pain, Spinal cord injury, Visual analogue scale.
8) conducted a before-and-after trial of SCI patients with pain, in which they found that gabapentin was effective in decreasing neuropathic pain refractory to conventional analgesics.
If the TPM/Oxycodone patch is shown to effectively reduce pain caused by PHN, it is very likely to be effective in treating many other neuropathic pain conditions, especially those where topical treatment could provide a therapeutic advantage (e.