Neuropathological features of TME include spongiform degeneration in the neuropil
of the brain, astrocytosis and the formation of PrP deposits of the TME agent.
3), and immunostained neuropil
in ganglia (unpublished data).
Survey of cerebellum white matter in the treatment group compared with normal cerebellum white matter tissue in control group demonstrated defects in the neuropil
tissue which was accompanied by decreased staining and increased interstitial space and decreased neuroglia cell condensation.
Learning a new skill such as playing a musical instrument, learning to type, or reading Braille requires extensive practice, and this practice is likely instrumental in changing the neuropil
in relevant brain regions (Kolb & Whishaw 1998).
NGF receptor immunoreactivity which was developed in the 3 layers of the cerebellar cortex in adult rats was decreased in the neuropil
of the molecular layer and in the cytoplasm of Purkinje neurons of rats of 24 months.
Studies by SEM showed not only the roughness of the microrelief ependyma, but and substantial hollowness in the neuropil
of various sizes (Figure 3).
In about 1% of investigated cell preparations, we found NPs in what looked like a loose neuropil
also containing synapses (Figure 5B).
Marked degenerative changes in the neuropil
were shown (Figure 3).
For instance, in  network percolation techniques are used to analyze phase transitions of dynamic neural systems such as those embedded within segments of cortical neuropil
PC] that possesses somewhat smaller variably stained neurons in a looser neuropil
broken up by bundles of fibers (Dewulf, 1971; Hirai and Jones, 1989).
En el estudio histopatologico se encontro perdida severa de la poblacion neuronal en todas las capas, ausencia de inflamacion, vacuolas de pequeno y gran tamano, tanto en el neuropil
, como en el soma neuronal y en la glia (figura 3).
However, the confirmed diagnosis of scrapie can only be made after performing immunohistochemistry and histopathology of CNS and lymphoid tissue of infected animals, which identifies in these tissues the PrPSc accumulation and spongiform lesions generated by a wide-spread vacuolisation of the neuropil
(Prusiner, 1998; Vaccari et al.