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Notch signaling |
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Notch signaling [′näch ‚sig·nəl·iŋ]
(embryology) An evolutionarily conserved developmental pathway utilized during the differentiation of a plethora of tissue types, in organisms as diverse as nematodes and humans. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | The extracellular domain (NECD) of the Notch receptor is pulled away from the intracellular domain (NICD) exposing a site at which two proteolytic cleavage events occur. Moreover, Wang says, the role his team has described for the Notch receptor in angiogenesis makes the molecule a potential target of drugs for head-and-neck cancers and perhaps for other solid tumors. Background Previously published studies have shown that Dll4 and its receptor family, known as the Notch receptors, play a role in vascular development, and further, that Dll4 is required for normal vascular development and is strongly expressed in tumor vessels. |
Notch receptor |
Notc 797 Notc 844 Notc 931 Notc 989 NOTCam notch notch notch notch notch notch above notch acuity notch antenna notch below notch brittleness notch depth notch ductility notch effect notch effects Notch family of receptors Notch filter Notch filter notch filters notch graft Notch Intracellular Domain notch joist Notch Noise Test notch ornament Notch pathway Notch receptor notch sensitivityNotch signaling Notch signaling pathway Notch signalling notch strength notch test notch up notch up notchback notchback notchbacks Notchboard Notchboard notched notched notched notched notched notched bar test Notched Constant Tension Load Notched Diametral Compression Notched Fracture Strength notched lap notched lap notched lap notched molding notched rafter Notched Tooth Notched Tooth Notched, Returned and Mitred Ends | |||||||
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