Notch signaling

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Notch signaling

[′näch ‚sig·nəl·iŋ]
(embryology)
An evolutionarily conserved developmental pathway utilized during the differentiation of a plethora of tissue types, in organisms as diverse as nematodes and humans.
References in periodicals archive ?
The Notch signalling pathway plays an important role in the processes of cell fate determination, including stem cell maintenance, differentiation, proliferation and apoptosis, which may contribute to the carcinogenesis of osteosarcoma.
Recent results have shown that Notch signalling is involved in osteosarcoma cell survival and contributes to the pathogenesis of human osteosarcoma.
The Notch signalling pathway is referred to as the 'aristocracy' on the 'social ladder' of pathways due to its preservation amongst the species and importance in both embryonal development and adult function [6].
Preclinical and clinical evidence supports the role of Notch signalling in both haematological malignancies and solid tumours.
They investigated the effect of a known signalling pathway called NOTCH on muscle differentiation, and found that differentiation of stem cells to muscle was initiated when NOTCH signalling proteins touched some of the cells.
Notch signalling controls pancreatic cell differentiation.
The authors have studied Notch signalling (part of the developmental signalling pathway) and showed a relationship to an inhibitor of the apoptosis gene family, namely survivin.
There are very few molecules that we know directly inhibit Notch signalling.
from one of the groups that has pioneered breast cancer stem cell research, describe the dysregulated pathways, such as the Notch signalling pathway, and the connection between Notch pathway activation of breast cancer stem cells, stem cell self-renewal pathways and how this might lead to novel therapeutic targets in both pre-invasive and invasive breast cancer.
London, June 22 (ANI): Researchers at Baylor College of Medicine say that they have made a new finding regarding the Notch signalling pathway in sensory organ precursor cells in the fruit fly that may help unravel the mystery behind an immunological disorder called WisKott-Aldrich syndrome.
Notch signalling has also been implicated in p53-mediated resistance to chemotherapy in MCF-7 cells and Woodward et al.