nuclear hormone receptor


Also found in: Medical.

nuclear hormone receptor

[¦nü·klē·ər ′hȯr‚mōn ri‚sep·tər]
(cell and molecular biology)
Any of a superfamily of proteins that directly regulate transcription in response to hormones and other ligands.
References in periodicals archive ?
The product is a first-in-class selective agonist to retinoic acid receptor alpha, a nuclear hormone receptor that regulates transcription.
GR is a member of the nuclear hormone receptor family of ligand-gated transcription factors.
The human pregnane X receptor (PXR) is a nuclear hormone receptor (NHR) that regulates the transcription of genes involved in xenobiotic metabolism and excretion.
The vitamin D receptor (VDR) is a nuclear hormone receptor that controls transcription of target genes.
LXR is a nuclear hormone receptor that is an important regulator of cholesterol metabolism in mammals.
The nuclear hormone receptor superfamily includes receptors for thyroid and steroid hormones, retinoids and vitamin D, as well as receptors for unknown ligands.
We have designed primers for polymerase chain reaction (PCR) to examine the possible involvement of ultraspiracle, (Usp), an insect nuclear hormone receptor and a putative receptor for JH in the process of histolysis.
They bind the peroxisome proliferator--activated receptor gamma, a nuclear hormone receptor that influences the expression of several human genes, including a fatty acid transporter, a fatty acid--binding protein, lipoprotein lipase, and a glucose transporter.
However, two key studies published in Nature and authored by Ember founders show that it is the inhibition of CDK5 phosphorylation of this nuclear hormone receptor that is the therapeutic driver of the anti-diabetic effect, while the receptor agonism is the driver of the adverse events associated with these therapies.
In addition, little work has been done on the agonistic and antagonistic activity of PBDEs against glucocorticoid receptor (GR) and thyroid hormone receptors (TRs) other than ERs and AR, and the nuclear hormone receptor activity of HO- and MeO-PBDEs is not fully understood.
The nuclear hormone receptor RORgamma is a novel target for the treatment of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and psoriasis.
Differentiation: interleukin-1/toll NF-[KAPPA]B, nuclear hormone receptor, apoptosis, receptor phosphotyrosine phosphatase
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