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nucleophile |
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nucleophileAtom or molecule that contains an electron pair available for bonding and in chemical reactions therefore seeks a positive centre, such as the nucleus of an atom or the positive end of a polar molecule (see covalent bond; electric dipole). In the Lewis electron theory (see acid-base theory), advanced by the U.S. chemist Gilbert Lewis (1875–1946) in 1923, nucleophiles are by definition Lewis bases. Examples include the hydroxide ion (OH−), the ions of the halogens chlorine, bromine, and iodine (Cl−, Br−, and I−, respectively), ammonia (NH3), and water (H2O). See also base; electrophile. nucleophile [′nü·klē·ə‚fīl] (physical chemistry) A species possessing one or more electron-rich sites, such as an unshared pair of electrons, the negative end of a polar bond, or pi electrons. Also known as electron donor. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| This side chain also interacts with nucleophiles to form adducts: the presumed cathepsin inhibitory activity is thought to reside in the active cysteine of cathepsin B, H, and L and of papain (Sudaranam et al. C-C Crossing Heleroarenes with Nucleophiles in Synthesis of As a bis-Bunte salt, disodium hexamethylene-1,6-bis-thiosulfate dihydrate suffers from insolubility in non-polar solvents and is very reactive with chemical nucleophiles. |
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