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nucleophile
(redirected from Nucleophilic)

    Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.02 sec.

nucleophile

Atom or molecule that contains an electron pair available for bonding and in chemical reactions therefore seeks a positive centre, such as the nucleus of an atom or the positive end of a polar molecule (see covalent bond; electric dipole). In the Lewis electron theory (see acid-base theory), advanced by the U.S. chemist Gilbert Lewis (1875–1946) in 1923, nucleophiles are by definition Lewis bases. Examples include the hydroxide ion (OH−), the ions of the halogens chlorine, bromine, and iodine (Cl−, Br−, and I−, respectively), ammonia (NH3), and water (H2O). See also base; electrophile.

nucleophile [′nü·klē·ə‚fīl]
(physical chemistry)
A species possessing one or more electron-rich sites, such as an unshared pair of electrons, the negative end of a polar bond, or pi electrons. Also known as electron donor.


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The opposite occurs for Cr(VI) species, which do not react with nucleophilic targets but can easily cross cell membrane through anion channels.
The effect of inhaled chromium on different exhaled breath condensate ... by Mutti, Antonio / Environmental Health Perspectives
It has been suggested that in latex vulcanization systems, where a thiourea is used as a secondary accelerator, it acts as a nucleophilic reagent enabling cleavage of sulfur bonds in the primary accelerator such as a thiuram (TMTD) or sulfenamide (CBS) at low temperatures of 100[degrees]C to 120[degrees]C.
Thiourea accelerators in the vulcanization of butyl elastomers by Waddell, Walter H. / Rubber World
Further investigation of the enzymatic mechanism of the mu-class glutathione S-transferase led to the structure determation of enzyme complexes with a transitionstate analogue, 1-(S-glutathionyl)-2,4,6-trinitrocyclohexadienate, and a product, 1-(S-glutathionyl)-2,4-dinitrobenzene, of a nucleophilic aromatic substitution (SNAr) reaction at 1.
Macromolecular crystallography and structural biology databases at ... by Gilliland, Gary L. / Journal of Research of the National Institute of Standards and Technology
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