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nucleotide excision repair |
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nucleotide excision repair [¦nü·klē·ə‚tīd ik′sizh·ən rē‚per] (cell and molecular biology) A five-step pathway that is the major repair system for removing bulky lesions in deoxyribonucleic acid. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Both of the latter lesions are repaired by nucleotide excision repair (NER) (Mitchell et al. For example, Cd(II), Cu(II), Co(II), and Ni(II) inhibit (at concentrations [greater than or equal to] 200 [micro]M) the in vitro DNA-binding activity of the human xeroderma pigmentosum group A protein, a critical damage recognition factor in nucleotide excision repair (Asmuss et al. We have genotyped polymorphic DNA repair genes preferentially involved with base excision repair (BER) and nucleotide excision repair (NER) activities (XRCC1, XRCC3, APE1, XPD) corresponding to the repair of X-ray- and UV light-induced DNA damage, respectively. |
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