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Nullisomy

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Nullisomy 

a type of genome mutation in which a pair of chromosomes that are normally present in the genome is missing. Organisms that exhibit nullisomy are called nullisomes. Nullisomy, especially in higher animals, usually results in death. Viable nullisomes can be found among polyploid plants; these nullisomes are used for nullisomic analysis and for establishing new, commercially valuable strains. Nullisomic analysis is used to determine genetic linkage groups and to study the traits that are controlled by these groups. The method is also applied to tissue-culture studies of human nullisomic cells.



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The following categories of sperm aneuploidy were included as dependent variables: disomy X (sperm FISH genotype X-X-21); disomy Y (Y-Y-21); disomy XY (X-Y-21); disomy 21 (X-21-21 or Y-21-21); overall hyperhaploidy involving chromosomes X, Y, and 21 (sum of XY, disomy X, disomy Y, and disomy 21); sex nullisomy (_21); 21 nullisomy (X_ or Y_); overall hypohaploidy involving chromosomes X, Y, and 21 (sum of sex nullisomy and 21 nullisomy); and diploidy.
A moderately increased prevalence of chromosomes X, Y, and 18 sperm aneuploidies was also observed in these workers but nullisomy was not scored (15).
 
 
 
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