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oncogene |
Also found in: Medical, Wikipedia, Hutchinson | 0.07 sec. |
oncogeneGene that can cause cancer. It is a sequence of DNA that has been altered or mutated from its original form, the proto-oncogene (see mutation). Proto-oncogenes promote the specialization and division of normal cells. A change in their genetic sequence can result in uncontrolled cell growth, ultimately causing the formation of a cancerous tumour. In humans, proto-oncogenes can be transformed into oncogenes in three ways: point mutation (alteration of a single nucleotide base pair), translocation (in which a segment of the chromosome breaks off and attaches to another chromosome), or amplification (increase in the number of copies of the proto-oncogene). Oncogenes were first discovered in certain retroviruses and were later identified as cancer-causing agents in many animals. See also J. Michael Bishop; Harold Varmus. oncogene any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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2005), although overexpression of ras p21 oncoproteins has been suggested to play a role in the initiation and progression of oral squamous cell carcinoma in smokers (Kuo et al. 7% of malignant lesions (high-risk viral subtypes HPV-16 and HPV-18 with 65% to 70% of lesions), and HPV-induced oncoproteins are implicated in the pathway from infection to malignancy (14,15). 29) These studies implicate ITAM-containing proteins as oncoproteins. |
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