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A fungus disease of the nails.



a disease of the nails caused by pathogenic fungi (seeDERMATOMYCOSES). Onychomycosis usually accompanies epidermophytosis; less commonly, trichophytosis, favus, candidiasis, and other fungal diseases. Onychomycosis, which rarely occurs as a separate disease, can arise in combination with fungal diseases of the skin and hair.

Acute inflammation is usually absent in onychomycosis. The nail plate becomes yellow, opaque, or brown, as well as brittle and thick: the nail often separates from the bed and becomes deformed. In some forms of onychomycosis, for example, when the accompanying disease is an epidermophytosis, all the nail plates are affected. In other forms, only a few nail plates are affected; for example, when trichophytosis is the accompanying disease, only the nails of the first and fifth toes have lesions. The pathological process may sometimes spread from the surrounding tissues to the nail plate. This occurs, for example, in onychomycosis that results from candidiasis, when the infection spreads from the borders of the nail.

Onychomycosis is treated by removing the nail plates with keratolytic plasters or with surgery and by applying antifungal agents. The disease is prevented by protecting the nail plates against injuries, treating microtraumas of the skin and nails with a 2 percent tincture of iodine, and by wearing shoes that fit properly. It is also important to control perspiration, to take proper hygienic care of the nails, and to wear slippers in baths, pools, and showers. On the public level, onychomycosis is prevented by disinfecting the patient’s personal belongings, by preventive checkups, and by inspection of public baths, pools, barbershops, and therapeutic baths. Cattle and other domestic animals are inspected for onychomycosis.


Sheklakov, N. D., and M. V. Milich. Gribkovye zabolevaniia cheloveka. Moscow, 1970.


References in periodicals archive ?
According to the report, the growth of the Global Dermatophytic Onychomycosis Therapeutics market is driven by several factors, the most important of which is the strong and promising pipeline of drugs that have disease-modifying properties and a better safety and efficacy profile.
Do not administer for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF.
Some common symptoms of onychomycosis include yellow streaks in the skin under the nail and on the underside of the nail, nail debris (the build up of tiny bits and pieces of skin and nail fragments under the nail), discoloration and thickening, brittle nails that break or crumble easily, white spots on the nail surface and often separation of the nail from the nail bed.
The Phase 1/2 trial will be conducted in patients with moderate to severe distal subungual onychomycosis and will evaluate 28 days of treatment with luliconazole 10% solution given once daily.
Reisberger EM, Abels C, Landthaler M, Szeimies RM: Histopathological diagnosis of onychomycosis by periodic acid-Schiff-stained nail clippings.
Early treatment before the disease progresses to total dystrophic onychomycosis can increase cure rate and may avoid the need for systemic treatments," wrote study author Dr.
Jublia is chosen for the treatment of mild to moderate onychomycosis, a common and destructive nail infection caused by dermatophyte fungi.
In both Phase 3 trials, tavaborole demonstrated better efficacy than ciclopirox lacquer, the only approved topical treatment for onychomycosis.
Manufactured by Erchonia, Lunula Laser is based on Low Level Laser Technology (LLLT) and provides effective treatment of onychomycosis without the risks and harmful side effects of oral medication, or the pain and recovery time associated with other laser treatments.
The four most advanced product candidates include one for the treatment of diaper dermatitis complicated by candidiasis, which is under FDA review, and three products, which are in or entering Phase 3 clinical trials for the treatment of seborrheic dermatitis, onychomycosis, and congenital ichthyosis.
The new oral antifungal agents for onychomycosis may not be living up to the fanfare that heralded their arrival.
Pro Nd:YAG laser to treat onychomycosis (nail fungus) in addition to its existing capabilities for hair removal and for the treatment of vascular and pigmented lesions.