Orotic Acid

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orotic acid

[ə′räd·ik ′as·əd]
C4H4O4N2 A crystalline acid which is a growth factor for certain bacteria and is also a pyrimidine precursor.

Orotic Acid


(also 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid or uracil-6-carboxylic acid), colorless crystals that are poorly soluble in water and organic solvents; melting point, 323°-345°C (with decomposition). Orotic acid was first extracted from cow’s milk in 1905 and later discovered in the milk of other animals and humans. Concentrated mainly in yeasts and in the liver, it is synthesized from aspartic acid and takes part in the biosynthesis of pyrimidine nucleotides, including uridine-5’-monophosphate and cytidine monophosphates. It also stimulates growth in plants and animals. The potassium salt of orotic acid is used in medicine to treat disorders in protein metabolism.

References in periodicals archive ?
For 2-deoxyinosine, adenosine, 2-deoxyadenosine, guanosine, 2-deoxyguanosine, succinyladenosine, orotic acid, thymine, dihydrouracil, dihydrothymine, uridine, 2-deoxyuridine, and 5-hydroxymethyluracil, sample concentrations were below the lower limits of quantification, as were the concentrations of inosine and N-carbamyl-[beta]-aminoisobutyric acid for children older than 1 year and N-carbamyl-[beta]-alanine for children older than 4 years of age.
Increased orotic acid (95 [micro]mol/mmol creatinine; reference, <10 [micro]mol/mmol creatinine) was observed in case 1, but not in case 2.