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A bone-forming cell of mesenchymal origin.



a cell that is involved in bone formation in vertebrate animals and man. Osteoblasts arise during the ossification of skeletal rudiments. In mature bone, they are found only in regions of injury, regeneration, and remodelling. They also take part in the formation and calcification of the intercellular substance of a bone.

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Besides osteoblasts, mesenchymal stem cells can also differentiate into the chondrocyte cells that make cartilage, the myocyte cells that help form muscles and the adipocytes, or fat cells.
The administration of zinc increased the collagen content mediated through activation of alkaline phosphatase and subsequent stimulation of collagen synthesis by osteoblasts.
The potential for osteoblast/cementoblast differentiation was further confirmed by qRT-PCR analysis, showing an increased expression of a key osteoblast transcription factor, RUNX2, and two osteoblast-specific early/late differentiation transcripts (ALP and OCN, respectively) in osteogenically-induced cells compared to non-induced (Figure 3C).
Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts," Science Advances, August 2016 DOI: 10.
sup][20],[21] Furthermore, recent studies have discovered that ENaC may also be expressed in osteoblasts and MSCs, for sodium concentration in the extracellular fluid may affect proliferation and differentiation of osteoblasts.
ALP has been generally considered a well-known early marker of differentiation in osteoblasts.
Biomarker measurements from blood and MSCs showed a shift toward bone resorption and adipocyte formation at the expense of osteoblast formation for both lead exposure and a high-fat diet.
In aggressive osteoblastoma the features are similar to benign osteoblastoma except for the morphology of osteoblasts which are large and have epitheloid appearance.
Derived from stem cells, osteoblasts are responsible for the laying down of new bone matrix.
All compounds were tested for osteogenic activity using primary cultures of mice osteoblasts following previously described protocol from our laboratory (Bhargava et al.
In the present study increase in osteocalcin level four weeks after surgery revealed that osteoblasts have became more active compared to presurgery period due to an imbalance in bone turnover, so the secretion of osteocalcin was increased after surgery.
Osteoblasts are target cells for IL-1 which in turn conveys messages to osteoclasts to resorb bone.