Osteoclast

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osteoclast

[′äs·tē·ə‚klast]
(histology)
A large multinuclear cell associated with bone resorption.
(medicine)
A large surgical apparatus through which leverage can be exerted to effect osteoclasis.

Osteoclast

 

a cell that is involved in the destruction and resorption of bone tissue in vertebrate animals and man. An osteoclast contains from three to several dozen nuclei and a great many lysosomes, whose hydrolytic enzymes upon release from the osteoclasts resorb the mineral matrix of bone and calcified cartilage.

References in periodicals archive ?
It is postulated that these enzymes are released from osteoclasts in osteopetrosis.
Number of osteoclasts was quantified in the histological sections on the mesial pressure side of disto-buccal root of right maxillary first molar near the furcation level.
2] were released and diffused to reach the osteoblast and stimulated the proliferation and differentiation of osteoblastic cells and inhibited the activity and differentiation of osteoclasts, thereby enhancing matrix deposition and, ultimately, new bone formation as shown in figure 3.
This protein is able to bind to RANK receptors on osteoclasts and prevent the binding of RANKL.
RANKL expression is stimulated in osteoblast/stromal cells by most of the factors that are known to stimulate osteoclast formation and activity.
The ability of the cells to differentiate into osteoclasts will verified using the same techniques as described during the bulk addition of proteins.
Because the experimental agent odanacatib reduces bone resorption without reducing the number of osteoclasts, it may preserve bone formation
Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro.
Recent findings indicate that T cells--immune cells involved in the attack on the brain and spinal cord in MS--stimulate proteins that increase osteoclasts, resulting in too much bone removal.
Odanacatib inhibits cathepsin K, the primary protease in osteoclasts that breaks down bone collagen during bone resorption.