extract inhibits the bone-resorbing activity of osteoclasts
It is postulated that these enzymes are released from osteoclasts
Number of osteoclasts
was quantified in the histological sections on the mesial pressure side of disto-buccal root of right maxillary first molar near the furcation level.
2] were released and diffused to reach the osteoblast and stimulated the proliferation and differentiation of osteoblastic cells and inhibited the activity and differentiation of osteoclasts
, thereby enhancing matrix deposition and, ultimately, new bone formation as shown in figure 3.
This protein is able to bind to RANK receptors on osteoclasts
and prevent the binding of RANKL.
RANKL expression is stimulated in osteoblast/stromal cells by most of the factors that are known to stimulate osteoclast
formation and activity.
The ability of the cells to differentiate into osteoclasts
will verified using the same techniques as described during the bulk addition of proteins.
Because the experimental agent odanacatib reduces bone resorption without reducing the number of osteoclasts
, it may preserve bone formation
Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts
Regulation of apoptosis in osteoclasts
and osteoblastic cells.
Recent findings indicate that T cells--immune cells involved in the attack on the brain and spinal cord in MS--stimulate proteins that increase osteoclasts
, resulting in too much bone removal.
Odanacatib inhibits cathepsin K, the primary protease in osteoclasts
that breaks down bone collagen during bone resorption.