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Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.
Adult animals lacking expression of the beta cell PDGF receptor were also less able than their peers to regenerate beta cells that were artificially damaged by a chemical compound, and they became severely diabetic after such treatment.
Early consolidation of the graft: the increased amount of PDGF in the graft initiates osteocompetant cell activity at an enhanced molecular rate.
The elevation of macrophages, endothelial cells and muscle cells to leading roles in PDGF production complicates the picture.
We look forward to further developing a novel therapy that blocks both VEGF and PDGF, as a potential way to improve vision in patients with wet AMD.
The company will use the proceeds from the contract for the development of an inhaled PDGF receptor kinase inhibitor to treat pulmonary arterial hypertension (PAH).
The researchers did not record any significant effect of injecting the drug on the levels of the other two mediators of angiogenesis, PDGF and HGF.
Proceeds from the contract will be used to develop an inhaled PDGF receptor kinase inhibitor for the treatment of pulmonary arterial hypertension (PAH).
Regeneron acquired full rights to antibodies targeting the PDGF (platelet derived growth factor) family of receptors and ligands in ophthalmology and all other indications and to antibodies targeting the ANG2 (angiopoietin2) receptor and ligand in ophthalmology.
For a long time, scientists have known that the protein PDGF, a growth factor, is essential to a cell-survival pathway that is required to keep these retinal cells alive.
Inhibition of PDGF is one such pathway and we are looking forward to developing a potential combination therapy together with Regeneron.
Recent clinical evidence has shown PDGF to be an additional key target for the treatment of wet-AMD.
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- PDGF A-chain
- PDGF receptor
- PDGF subunit A
- PDGF subunit B
- PDGF, B chain
- PDGFA-Associated Protein 1