PEO

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PEO

(Professional Employer Organization) A company that serves as an off-site human resources department to small and medium-sized organizations. A fast-growing business segment after the new millennium, PEOs are relationship-focused and take responsibility for HR administration plus legal and regulatory compliance issues. The quality of employee benefits in areas of insurance and workers compensation is often improved due to the expertise and group purchasing power of a PEO.
References in periodicals archive ?
Minor patients with two mutations in POLG , DGUOK , TK2 , and SUCLA2 genes showed a wide phenotypic spectrum, including Alpers' syndrome, early-onset hepatocerebral disease, myopathy, and ophthalmoparesis.
28],[29] Among these genes, TK2 , DGUOK , and SUCLA2 genes encode proteins that maintain the mitochondrial dNTP pool, and POLG gene is essential for mtDNA replication.
DOES THE mtDNA CONTENT IN BLOOD SAMPLES FROM PATIENTS WITH POLG MUTATIONS CORRELATE WITH AGE OR DISEASE?
Mutations in the POLG gene do not always cause mtDNA depletion in blood (Fig.
The mtDNA content was not reduced in blood samples from 97 symptomatic individuals with a single mutation or unclassified variant in POLG, DGUOK, TK2, or TYMP (mean mtDNA content 105%, 98%, 118%, and 141% of the age-matched pooled control value, respectively) (Fig.
DNA sequencing has becomes an integral part of clinical diagnoses, and for mitochondrial disorders, in particular, it has become essential because POLG is a major disease locus.
The POLG mutations were first identified in Alpers syndrome in 1999.
96) Finally, to definitively confirm the pol [gamma]-related mutations, nuclear DNA sequencing of POLG and related genes encoding associated proteins (eg, POLG2, PEO1 [C10ORF2], MPV17) is needed (Figure 3).