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Centroacinar Cells
(redirected from Pancreatic duct cell)

   Also found in: Wikipedia 0.01 sec.
Centroacinar Cells 

in animals and man, part of the basic mass of the exocrine portion of the pancreas. The cells constitute the terminal branchings of the intercalary acinar sections of the excretory ducts in the caudal part of the gland. The centroacinar cells are involved in the formation and secretion of sodium bicarbonate—a component of pancreatic juice.



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Eosinophilic pan-nuclear inclusion bodies were frequently seen in acinar cells and pancreatic duct cells (Fig 2).
Testing the idea that adult pancreatic duct cells might be able to revert to multipotent cells, which then can differentiate into islet cells when appropriately stimulated, scientists at Harvard Medical School in Boston, MA digested human pancreatic tissue that normally is discarded after isolating islets.
The transgenic mouse models express growth factors which cause pancreatic phenotypic changes, including pancreatic duct cell proliferation, differentiation of certain pancreatic cells into other endodermal derivatives, increased islet and ductule development and intra islet ductule formation and proliferation of pancreatic cells generally.
 
 
 
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