Drugs like proton pump inhibitors, such as Prilosec[R] or Nexium[R], block the parietal cells
from excreting stomach acid.
Thus, the proton pumps in parietal cells
are inactivated by higher concentration of PPIs and for a longer time in CYP2C19 mutant homozygotes resulting in a stronger acid inhibition and higher intragastric pH.
1) an autoimmune process targeting parietal cells
or intrinsic factor, and
In the trained group, parietal cells
connected to cells in two brain areas that weren't accessed by those cells in untrained animals.
According to some authors, those receptors are located at parietal cells
and at histamine secretory cells.
Brodiaea, Dipterostemon, Dichelostemma, and Muilla (formerly Alliaceae, now Themidaceae) are also crassinucellate (Berg, 1978, 1996), whereas all members of Alliaceae lack parietal cells
Belmazol, used primarily for hyperacidity problems related to ulcers and gastroesophageal reflux disease, is a proton pump inhibitor which inhibits the hydrogen/potassium ATPase enzyme system at the secretory surface of gastric parietal cells
in 1989, was the first in a class of medications called proton pump inhibitors (PPIs) that block acid production by inhibiting an enzyme system (hydrogen-potassium ATPase) on the surface of the stomach's parietal cells
Immunologically, the hallmark of pernicious anemia is the presence of autoantibodies to gastric parietal cells
(AGPA), proton pump (H+K+ATPase), and to the cobalamin-absorbing protein, intrinsic factor.
Wilson speculated that marginal ulcers are caused by increased gastric acid production in the setting of surgically induced mucosal disruption and ischemia, and that proton pump inhibitor therapy is partially protective because it squelches acid production by parietal cells
in the gastric pouch.
Chiba T, Fisher SK, Park J, Seguin EB, Agranoff BW, Yamada T (1988) Carbamoylcholine and gastrin induce inositol lipid turnover in canine gastric parietal cells