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Pericyte
(redirected from Pericytes)

   Also found in: Medical, Wikipedia 0.01 sec.
pericyte [′perĀ·ə‚sīt]
(histology)
A mesenchymal cell found around a capillary; it may or may not be contractile.

Pericyte 

(also Rouget cell), a branching cell in the wall of a blood-carrying capillary. The cytoplasm of pericytes is characterized by the presence of fibrillar elements and micropinocytotic vesicles, whose membranes exhibit adenosine triphosphatase activity. The outgrowths of pericytes surround the capillaries and, penetrating the basement membrane, either come into contact with the endothelial cells or are separated from the cells by a narrow space. Some scientists consider pericytes to be partially differentiated cells, capable of being transformed into other cellular elements of connective tissue. Others consider pericytes to be differentiated contractile elements, capable of changing the lumen of the capillary. Still others admit the existence of various types of pericytes, capable of regenerative or contractile functions.



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In addition to synthesizing components of the extracellular matrix, fibroblasts associated with tumors also express FAP, a particular protease that cuts up other proteins while pericytes are important to the function of the new blood vessels that develop in tumors.
Geraldes studied the effects on retinal pericytes (supportive tissue cells found near small blood vessels) in a bid to expand the search for what goes wrong as glucose levels climb.
This pathway is believed to damage Schwann cells, causing neuropathy, and pericytes in the retinal capillaries, causing retinal microaneurysms.
 
 
 
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