Hugo Schiff

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Schiff, Hugo


Born Apr. 26, 1834, in Frankfurt am Main; died Sept. 8, 1915, in Florence. Italian chemist. German by nationality.

A student of F. Wöhler, Schiff was a privatdocent at the University of Bern (1857). He later emigrated to Italy, where he worked in Florence from 1863 to 1876 and from 1879 to 1915. From 1876 to 1879 he was a professor at the University of Turin.

Schiff’s main works were devoted to organic chemistry. Schiff discovered the condensation reaction of aromatic amines with aldehydes (1864) and investigated the products of the reaction, which have come to be called Schiff bases. He synthesized populin (1868) and digallic, or tannic, acid (1873). He proposed qualitative reactions for aldehydes (with fuchsin sulfurous acid; called the Schiff reaction), urea, and pentosanes. Schiff invented the azotometer (or nitrometer), a device for determining nitrogen according to the method proposed by J. B. Dumas.


“Hugo Schiff.” In the collection Berichte der Deutschen chemischen Gesellschaft, fasc. 48, vol. 2. Berlin, 1916. Pages 1566–67.
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insidiosum stains well with Gomori methenamine silver and periodic acid-Schiff stain.
Formalin-fixed, paraffin-embedded, and frozen sections of kidney tissue were cut and stained with periodic acid-Schiff stain, colloidal iron, immunofluorescence (IF) stain, and electron microscopy (EM) for general histologic examination as previously described.
11) Typical cytoplasmic glycogen can be demonstrated on periodic acid-Schiff stain, whereas the muscle characteristics of the cells can be confirmed by strong positive reaction for desmin, muscle-specific actin, and myoglobin.
A periodic acid-Schiff stain indicated absence of glycogen deposits.
Periodic acid-Schiff stain failed to demonstrate glycogen particles in the cytoplasm of the cells.
3,4) Mucicarmine and periodic acid-Schiff stain the characteristic thick mucopolysaccharide capsule.
Periodic acid-Schiff stain demonstrated the presence of positive granules in the cytoplasm of nucleated red blood cells and some blasts (Figure 2).
Mucicarmine stain was negative and periodic acid-Schiff stain was positive and seen decorating the cell membrane.
A periodic acid-Schiff stain was focally positive, and the positivity was abolished by diastase digestion.
Psammomatous calcification and periodic acid-Schiff stain positive hyaline basement membrane material were observed in the tumour stroma (Fig.
The cytoplasm of the atypical cells was stained with periodic acid-Schiff stain, confirming the diagnosis of extramammary Paget disease.