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(myocardosis), a term often applied to a broad group of heart diseases; specifically, noninflammatory lesions of the heart muscle (myocardium) resulting from a disturbance in myocardial metabolism. Among the causes of cardiomyopathy are nutritional disorders (alimentary dystrophy and avitaminosis, for example); protein metabolism disorders in hepatic or renal insufficiency and podagra; disturbances of carbohydrate metabolism (diabetes mellitus) and electrolyte metabolism; and endocrine disorders such as those associated with thyrotoxicosis and with hypoxia in impairment of coronary circulation, anemia, and mountain sickness. Myocardosis may also be caused by overstraining the myocardium and by exogenous poisons, such as carbon monoxide and alcohol.

In many cases the patient has no specific symptoms in the early stages; however, there may be shortness of breath and disagreeable sensations in the heart. Cardiomyopathy is manifested by dull, distant heart sounds, electrocardiographic changes, systolic murmur, extrasystole, and, more rarely, other types of arrhythmia. Severe cardiomyopathy weakens the heart contractions and may cause cardiac insufficiency. The changes associated with cardiomyopathy are usually reversible and disappear with the elimination of the underlying disease.

The cure includes treatment of the underlying disease and administration of agents that improve metabolic processes in the myocardium.


Kedrov, A. A. Bolezni myshtsy serdtsa. Leningrad, 1963.


References in periodicals archive ?
Peripartum cardiomyopathy searching for a better understanding.
Clinical management of gravid women with peripartum cardiomyopathy.
Two previously published studies from Haiti and South Africa found a higher incidence of peripartum cardiomyopathy than in other parts of the world but essentially all the participants were black.
You get by with diuretics, digoxin, and hydralazine during pregnancy" for peripartum cardiomyopathy, Dr.
On the research front, animal studies and now preliminary data from a very small number of women with acute severe peripartum cardiomyopathy suggest that bromocriptine, an inhibitor of prolactin, may have a favorable effect on outcomes (Circulation 2010;121: 1465-73).
We also confirm that some cases of peripartum cardiomyopathy, which occurred in the context of familial DCM in 2 families, are part of the spectrum of familial DCM.
A significant subset of peripartum cardiomyopathy is the initial manifestation of familial dilated cardiomyopathy.
Women who develop peripartum cardiomyopathy are likely to have poor outcomes in subsequent pregnancies, even if left ventricular function returned to normal after the disorder resolved, according to Dr.
7) Patients with valvular heart disease, hypertension, ischaemic, pericardial or congenital heart disease, diabetes or alcoholic cardiomyopathy and women who fulfilled the criteria for peripartum cardiomyopathy were excluded.
The 1 death among 1,052 patients treated with Injectafer in the postpartum/ heavy uterine bleeding trials was in a woman found to have peripartum cardiomyopathy on autopsy.
Three years ago, she was found to have the rare heart defect peripartum cardiomyopathy (PPCM), which restricts blood flow from the, heart to the rest of the body.
Focus on the woman's health in those rare cases of peripartum cardiomyopathy, said Thomas S.