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Philadelphia chromosome |
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Philadelphia chromosome [¦fil·ə¦del·fyə ′krō·mə‚skōp] (pathology) An abnormally small G-group chromosome found in the hematopoietic cells of most patients with chronic granulocytic leukemia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Additional FISH studies looking for the Ph chromosome in normal granulocytes would be useful in excluding CML. The Ph chromosome is the result of a translocation between two genes, which brings together the BCR gene on chromosome 22 and the proto-oncogene ABL on chromosome 9. The Ph chromosome is the result of a translocation between two genes, which brings together the BCR (breakpoint cluster region) gene on chromosome 22 and the proto-oncogene ABL (Ableson leukemia virus) on chromosome 9. |
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