I didn t know it at the time, but I was working with a bacterial strain that had a CRISPR system, so I was unconsciously selecting phages
that were likely to have anti-CRISPRs, he recalls.
Sorek's team used this strategy to identify and analyze phages
present in the gut microbiota of a cohort of European individuals.
It was like lightning struck," he says of learning that phages
were not used in the United States, despite all the country's advanced medical technologies.
Several filamentous phages
other than CTX[PHI] are found to be integrated at the dif loci of V.
For example, the relatively narrow host range of most phages
which caused many of the early attempts at phage
therapy to fail can be overcome by isolating phages
that have a broad host range within the species being targeted.
The scientists also have tested the phages
on their prime target: refrigerated fresh-cut lettuce.
Immune cells in the brain cleared the phages
along with the plaque fragments, says Solomon.
GangaGen has demonstrated in production animal trials that we can isolate and use phages
efficaciously, with full regard for safety, and that the phages
are benign to animals, humans and the environment.
They infect target bacteria, make multiple copies of themselves, and then break out of the bacterial cell by perforating the cell wall, using an enzyme lysine produced by the phages
To the Editor: In the summer of 2004, genitourinary medicine clinics in London reported cases of Shigella sonnei with a novel phage
type pattern (later designated PTQ).
This is not surprising because lambda phage
cloning procedures describe stable storage of those phages
in SM buffer for several years (11).
are viruses that infect bacteria but are not used in the UK, where hospital-acquired infections claim up to 5,000 lives a year and cost the NHS pounds 1billion.