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C12H12N2O3 A crystalline compound, 5-ethyl-5-phenylbarbituric acid, with a slightly bitter taste, melting at 174-178°C; soluble in water, alcohol, chloroform, and ether; used in medicine as a long-acting sedative, anticonvulsant, and hypnotic.



(trade name, Luminal), a medicinal preparation of the barbiturate group. Taken in powder or tablet form, phenobarbital is a long-acting soporific and is used in the treatment of such conditions as epilepsy and vascular spasms. Phenobarbital may be combined, in tablet form, with various other substances, including analgesic and spasmolytic preparations (for example, Andipal, Camphodal, or Paluphin).

References in periodicals archive ?
Although hemodialysis is a well-known therapeutic approach in severe phenobarbital intoxication, we thought it was appropriate to present our case in order to draw attention to the possibility that more efficient results could be obtained with single-pass albumin dialysis (SPAD).
The administration of 20 mg/kg of phenobarbital decreased serum NO concentration in full-term neonates with HIE, but had no effect on clinical, EEG, and MRI changes.
Although the upregulation of the GABA-A receptors plays a vital role for the emergence of the effects of phenobarbital and primidone, these agents may also act through the inhibition of sodium, potassium, and calcium ion channels.
Ito T, Katagiri C, Ikeno S, Takahashi H, Nagata N, Terakawa N: Phenobarbital following phototherapy for Crigler-Najjar syndrometype II with good fetal outcome: a case report.
5) Our patient did not consume alcohol and had no biological signs of malabsorption, but she was taking Phenobarbital for about 45 years.
There were 94 infants who were randomly assigned, 50 to the phenobarbital group and 44 to the normal saline group (placebo).
Switch to Librium (chlor-diazepoxide) or phenobarbital in an outpatient setting at a time when patients are physiologically improved.
phenobarbital, induced substantial regionally specific cell death, In vitro study [10] has demonstrated that the secretion of testicular testestrone is in response to the stimulatory action of gonadotrophins.
The recalled product is identified as Phenobarbital Tablets, USP 32.
A single bottle of hydrocodone bitartrate and acetaminophen tablets was incorrectly labeled as phenobarbital.
The likelihood of fractures was highest for persons taking phenytoin followed by carbamazepine, other, phenobarbital, gabapentin and clonazepam.
The panel also concluded that intrauterine exposure to anticonvulsant polytherapy or to valproate monotherapy probably results in poor cognitive outcomes, but panel members were less confident regarding the current weight of evidence for phenytoin or phenobarbital.