was used as a substrate to evaluate ARES activity.
An Open-Label Crossover Study of the Pharmacokinetics of Ornithine Phenylacetate
(OCR-002) after IV and Oral Doses in Subjects with Cirrhosis" - Publication Number: 501; Select findings include:
The carboxylic acid ester phenylacetate
and its analogs have also been linked to breast neoplasms (Sawatsri et al.
Two absorption bands at 1458, 1349 cm-1 were observed due to presence of NO2 substituent on phenylacetate
subfasciatus in the field, and also showed that traps baited with methyl phenylacetate
Machado and Pinheiro da Silva (13) recommend sodium phenylacetate
, sodium benzoate, and sodium phenylbutyrate to provide alternative pathways to eliminate ammonia via renal excretion.
Over the following 2 weeks, the patient was treated with intravenous sodium benzoate/sodium phenylacetate
and L-arginine to reduce the blood ammonia concentration.
PON is associated with paraoxon hydrolysis and represents enzymatic activity, but phenylacetate
hydrolysis (ARE) reflects the mass of enzyme protein [15, 46, 47].
Arilesterase activity in serum was determined spectrophotometrically using the phenylacetate
(Merck-Schardt) as a synthetic substrate.
These formulations will be compared against an immediate release oral solution of drug candidate OCR-002 and ammonia-lowering agent glycerol phenylbutrate (RAVICTI(R)), a pre-pro drug of phenylacetate
, a component of OCR-002.
According to media reports, recent trends of illicit precursor trafficking, particularly of ethyl phenylacetate
and ephedrine, involve smuggling operations between Hong Kong, Mainland China, and Latin America.
He was started on ammonia scavenging agents like sodium phenylacetate
, sodium benzoate, and sodium phenylbutyrate.