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Philadelphia chromosome |
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Philadelphia chromosome [¦fil·ə¦del·fyə ′krō·mə‚skōp] (pathology) An abnormally small G-group chromosome found in the hematopoietic cells of most patients with chronic granulocytic leukemia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Scientists have continued to hammer away at the so-called Philadelphia chromosome, a shortened chromosome 22. In most cases, a genetic abnormality involving the Bcr-Abl protein, a tyrosine kinase encoded by the Philadelphia chromosome, results in constantly activated growth of cancer cells. The perfect date between Gleevec and Chronic Myeloid Leukemia (CML) will however be hard to achieve by other inhibitors currently in development, because of CMLis strong link to a sole pathogenic event - the Philadelphia chromosome. |
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