Philadelphia chromosome


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Philadelphia chromosome

[¦fil·ə¦del·fyə ′krō·mə‚skōp]
(pathology)
An abnormally small G-group chromosome found in the hematopoietic cells of most patients with chronic granulocytic leukemia.
References in periodicals archive ?
Diversity of breakpoints of variant Philadelphia chromosomes in chronic myeloid leukemia in Brazilian patients.
In 2005, several research groups found that the JAK2 (Janus kinase) mutation was common to the Philadelphia chromosome negative MPNs PV, ET, and PMF.
In addition, patients who do not achieve a major reduction of Philadelphia chromosomes in 6-12 months of therapy appear to have less durable remissions.
According to the company, Imatinib mesylate tablets are also indicated in adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia; adult patients with myelodysplastic/myeloproliferative diseases associated with PDGFR gene re-arrangements; and adult patients with aggressive systemic mastocytosis without the D816V c-Kit mutation or with c-Kit mutational status unknown.
Prognosis for children, adolescents, and adults is influenced by their karyotypes and cytogenetic molecular features, including the so-called Philadelphia chromosome (translocation of chromosomes 9 and 22, q34, and q11) and translocation of gene 411.
The European Medicines Agency has validated US-based pharmaceutical company Bristol-Myers Squibb Co's (NYSE: BMY) Type II variation/Extension of Application for Sprycel (dasatinib) to treat children and adolescents aged one year to 18 years with chronic phase Philadelphia chromosome positive chronic myelogenous leukemia and to include the powder for oral suspension, the company said.
The genetic hallmark of CML is the Philadelphia chromosome, an abnormality resulting in a fusion of the BCR and ABL genes.
s (NYSE: PFE) Besponsa (inotuzumab ozogamicin) in the European Union as monotherapy for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor Philadelphia chromosome negative acute lymphoblastic leukemia and Philadelphia chromosome positive ALL, who have previously failed treatment with at least one tyrosine kinase inhibitor, the company said.
Molecular Responses with Ponatinib in Patients with Philadelphia Chromosome Positive (Ph+) Leukemia: Results From the PACE Trial
The Philadelphia chromosome contains the Bcr-Abl hybrid gene, which leads to over-production in the bone marrow of tyrosine kinase, an enzyme that causes too many stem cells to develop into white blood cells (granulocytes or blasts).
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